Vitamins

Vitamin B6

A versatile B vitamin involved in over 100 enzyme reactions.

~10% of the US population has inadequate vitamin B6 status; rates increase with age

Why it matters for longevity

Vitamin B6 is a cofactor in more than 100 enzyme reactions, primarily involved in protein metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), and immune function. It also helps regulate homocysteine levels, and elevated homocysteine is an independent risk factor for cardiovascular disease and cognitive decline. Low B6 status is associated with increased inflammation and higher CRP levels.

How much you need

RDA

1.3mg for adults 19-50, 1.7mg for men over 50, 1.5mg for women over 50

Optimal

Researchers suggest 2-10mg daily, with higher amounts potentially beneficial for reducing inflammation in older adults.

Signs you might be low

  • Cracked, sore lips
  • Mood changes and irritability
  • Weakened immune function
  • Tingling or numbness in hands and feet
  • Confusion or brain fog

Best food sources

FoodPer serving
Chickpeas, canned (1 cup)1.1mg
Beef liver (3 oz)0.9mg
Yellowfin tuna (3 oz)0.9mg
Chicken breast (3 oz)0.5mg
Banana (1 medium)0.4mg

Key research

Morris MS et al. (2008). Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. Journal of Nutrition, 140(1), 103-110.

Track your vitamin b6 with Biohack

Every meal scored for longevity. 23 nutrients tracked automatically. AI coaching to close your gaps.

← All nutrients

Related articles