Vitamin B6
A versatile B vitamin involved in over 100 enzyme reactions.
~10% of the US population has inadequate vitamin B6 status; rates increase with age
Why it matters for longevity
Vitamin B6 is a cofactor in more than 100 enzyme reactions, primarily involved in protein metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), and immune function. It also helps regulate homocysteine levels, and elevated homocysteine is an independent risk factor for cardiovascular disease and cognitive decline. Low B6 status is associated with increased inflammation and higher CRP levels.
How much you need
1.3mg for adults 19-50, 1.7mg for men over 50, 1.5mg for women over 50
Researchers suggest 2-10mg daily, with higher amounts potentially beneficial for reducing inflammation in older adults.
Signs you might be low
- Cracked, sore lips
- Mood changes and irritability
- Weakened immune function
- Tingling or numbness in hands and feet
- Confusion or brain fog
Best food sources
Key research
Morris MS et al. (2008). Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. Journal of Nutrition, 140(1), 103-110.
Track your vitamin b6 with Biohack
Every meal scored for longevity. 23 nutrients tracked automatically. AI coaching to close your gaps.
Related articles
The 23 Nutrients That Predict How Long You Live
Longevity is not about calories. Peer-reviewed research points to 23 specific micronutrients that correlate with a longer, healthier life.
Why Tracking Macros Misses the Point
Counting protein, carbs, and fat tells you almost nothing about how long you will live. Micronutrients are the missing piece.