Fatty Acids

Omega-3 (EPA + DHA)

The fatty acids your brain and heart depend on.

~68% of Americans have an Omega-3 Index below 4%, considered high risk

Why it matters for longevity

Omega-3 fatty acids EPA and DHA reduce chronic inflammation, lower triglycerides, and support brain structure throughout life. Large cohort studies consistently link higher omega-3 blood levels with reduced cardiovascular mortality and slower cognitive decline. The Framingham Heart Study found that participants in the top quartile of DHA levels had a 47% lower risk of developing dementia.

How much you need

RDA

250-500mg combined EPA and DHA daily (AHA recommendation)

Optimal

Longevity researchers suggest 1,000-2,000mg combined EPA and DHA daily, targeting an Omega-3 Index of 8-12%.

Signs you might be low

  • Dry, flaky skin
  • Difficulty concentrating or brain fog
  • Joint stiffness and pain
  • Mood changes or low mood

Best food sources

FoodPer serving
Atlantic mackerel (3 oz)2,670mg
Wild salmon (3 oz)1,800mg
Sardines (3 oz)1,360mg
Anchovies (3 oz)1,290mg
Herring (3 oz)1,710mg

Key research

Harris WS et al. (2018). The Omega-3 Index and relative risk for coronary heart disease mortality. Atherosclerosis, 262, 21-27.

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