Folate (Vitamin B9)
Essential for DNA repair and methylation.
~20% of adolescent girls and women of childbearing age have inadequate folate status
Why it matters for longevity
Folate is critical for DNA synthesis, repair, and methylation, a process that regulates gene expression throughout life. Inadequate folate leads to elevated homocysteine, a marker linked to cardiovascular disease and cognitive decline. Folate also plays a key role in preventing neural tube defects during pregnancy. Research from the Nurses Health Study linked adequate folate intake to a 20% reduction in colon cancer risk.
How much you need
400mcg DFE for adults, 600mcg for pregnant women
Researchers recommend 400-800mcg daily from food sources like leafy greens. Natural food folate is preferred over synthetic folic acid.
Signs you might be low
- Fatigue and weakness
- Sore mouth and tongue
- Gray hair (premature)
- Poor concentration
Best food sources
Key research
Giovannucci E et al. (1998). Multivitamin use, folate, and colon cancer in women in the Nurses Health Study. Annals of Internal Medicine, 129(7), 517-524.
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